Recent Developments in RNA Secondary Structure Prediction
نویسنده
چکیده
Here we discuss recent developments in predicting RNA secondary structure, giving an overview of methods used, including energy minimization and Boltzmann sampling, a probabilistic approach, and the use of fragment libraries generated from high resolution three-dimensional RNA crystal structures. An example for each of these three methods is discussed in detail (namely Sfold, CONTRAfold and MC-FOLD respectively), and compared using the P4-P6 domain of Tetrahymena ribozyme as the test case. In all instances, the predicted secondary structures were very similar to the native one, with the main helices being captured quite accurately. This mini-review is by no means exhaustive, but gives a guide to the current research in pushing the field of understanding and predicting RNA structure.
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